Promotive Communications

Lab Focus MayJune_digital

Laboratory Focus is Canada's leading editorial-based lab publication. Providing readers with the latest technology updates through application and tech notes, as well as covering new products and trends in laboratories across Canada.

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R&D News ......................... 1 Pharma Notes .................... 7 Appointments .................... 6 New Products .................. 15 Calendar .......................... 17 App Reviews ..................... 19 P h a r m a c e u t i c a l c l i n i c a l c h e m i c a l f o o d e n v i r o n m e n t w w w . l a b o r a t o r y f o c u s . c a may/June 2015 volume 19, number 2 Publications Mail Registration Number: 40052410 a better way to build dna scaffolds DNA nanotechnology," Sleiman says. "This could provide access to designer DNA materials that are economical and can compete with cheaper, but less versatile tech- nologies. In the future, uses could range from customized gene and protein synthesis, to applications in nanoelectronics, nano-optics, and medicine, including diagnosis and therapy." Funding for the research was provided by the Natural Sciences and Engineering Research Council of Canada, the Fonds de recherché du Québec – Nature et technolo- gies, the Canada Foundation for Innovation, the Canadian Institutes of Health Research, and the Cen- tre for Self-Assembled Chemical Structures. To see this story online visit http://www.laboratoryfocus. ca/?p=2977 In new research published in Nature Communications, McGill University chemistry professor Hanadi Slei- man and her team at McGill say that they have devised a new technique to create much longer strands of DNA with custom-designed se- quence patterns. What's more, this new approach also produces large amounts of these longer strands in just a few hours, making the pro- cess potentially more economical and commercially viable than exist- ing techniques. The new method involves piec- ing together small strands one after the other, so that they attach into a longer DNA strand with the help of an enzyme known as ligase. A second enzyme, polymerase, is then used to generate many cop- ies of the long DNA strand, yielding larger volumes of the material. The polymerase process has the added advantage of correcting any errors that may have been introduced into the sequence, amplifying only the correctly sequenced, full- length product. The team used these strands as a scaffold to make DNA nano- tubes, demonstrating that the technique allows the length and functions of the tubes to be pre- cisely programmed. "In the end, what we get is a long, synthetic DNA strand with exactly the sequence of bases that we want, and with exactly as many repeat units as we want," explains Sleiman, who co- authored the study with Graham Hamblin, who recently completed his doctorate, and PhD student Janane Rahbani. "This work opens the door toward a new design strategy in Plate-based drug and toxin screening using multiplexed benchtop flow cytometry Page 8 ultra-fast ph-Gradient ion exchange chromatography Page 12 Prof. Hanadi Sleiman (left) and Janane Rahbani in their lab at McGill. Photo: McGill University

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