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Lab MayJune2017_digital (1)

Laboratory Focus is Canada's leading editorial-based lab publication. Providing readers with the latest technology updates through application and tech notes, as well as covering new products and trends in laboratories across Canada.

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vwr.com/antibody Sample Preparation SPE Columns, Discs & Plates QuEChERs Micro Extraction Syringe Filters Syringeless Filters TFF Sample Handling LC/MS Certified Vials Microsampling Vials Headspace Vials TOC Vials Storage Vials EPA Vials RSA Vials Microplate & Mats Sample Separation Analytical Columns Preparative Columns Capillary Columns GC Columns FLASH Columns Bulk Silica & Sorbents Empty Columns Instruments & Accessories LC & GC Systems HPLC Fittings & Hardware GC Septa & Liners Lamps Syringes Gas Generators HPLC Grade Solvents Valves Safety Caps VWR HAS YOUR CHROMATOGRAPHY SOLUTION VWR provides comprehensive information and services on instruments and consumables for a wide variety of chromatography techniques and applications to support your demanding requirements, from research labs to production and manufacturing facilities. For more information or to download the VWR Chromatography Source Guide, visit vwr.com/chromatography 2 May/June 2017 Laboratory Focus www.laboratoryfocus.ca news that genome editing could in- advertently disable a tumour- suppressor gene or activate a cancer-causing gene. Consider the possibility of an off-target effect where two different chromosomes are joined in a phenomenon called translocation. Translo- cation is the cause of chronic myeloid leukemia and other conditions. Off-target effects occur be- cause CRISPR has two parts. The RNA part targets the site in the genome specified by the RNA's string of nucleo- tides. The enzyme cuts the genome at this site. However, a genome can have more than one site where the same string of nucleotides appears. The cutting enzyme of CRIS- PR does not stop at one cut. The enzyme "still has energy to bind with off-target site, so it can still cleave those sites," said Joung. "More work may be needed to increase the fidelity of CRIS- PR-Cas9 with regard to off-tar- get mutation…," according to the authors of the Unexpected mutations after CRISPR-Cas9 editing in vivo study. They recommend that fu- ture studies use new CRISPR methods and that reagents consider using WGS analysis to determine the presence of off-target mutation in vivo. To see this story online visit http://laboratoryfocus.ca/ ottawa-researchers-kill-brain- cancer-in-mice-with-combi- nation-immunotherapies/ continued from page 1 twitter.com/@LabFocus linkedin.com/company/ laboratory-focus facebook.com/LaboratoryFocus PUBLISHER/EDITOR-IN-CHIEF Terri Pavelic EDITOR Nestor Arellano CONTRIBUTING WRITERS Nicolas Paris Klemen Zupancic Sikander Gill Maxim Slyadnev Alexander Syroganov GRAPHIC DESIGNER Elena Pankova CONTROLLER John R. Jones MARKETING MANAGER Mary Malofy CIRCULATION DIRECTOR Mary Labao mary@promotivemedia.ca Tel: 905-841-7389 OFFICE: 226 Edward St. Unit 1 Aurora, ON L4G 3S8 Phone: 905-727-3875 Fax: 905-727-4428 E-mail: laboratory_focus@ promotivemedia.ca SUBSCRIPTION INQUIRIES mary@promotivemedia.ca Fax: 905-727-4428 Laboratory Focus is published 4 times per year by Promotive Communications Inc. Legal Depository: National Library of Canada ISSN 40052410 Subscription rate in Canada $35/year; USA $60/year; other countries $100/year. All rights reserved. No part of this publication may be reproduced without written consent. Publications Mail Registration Number: 40052410 Return undeliverable Canadian addresses to circulation dept: 1-226 Edward Street, Aurora, ON L4G 3S8 E-mail: mary@promotivemedia.ca All opinions expressed herein are those of the contributors and do not necessarily reflect the views of the publisher or any person or organization associated with the magazine. If you would like to order hard copy or electronic reprints of articles, contact www.laboratoryfocus.ca

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